Drink trial

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Drink trial

The DRINK trial will be carried out at Addenbrookes Hospital in Cambridge and will take place over 12 weeks. DRINK is a feasibility trial, this means it is a smaller trial done over a shorter period of time and is designed to answer the question of whether a large trial is possible. We want to find out if participants are able to drink enough water daily to stop vasopressin production by the brain and whether it is safe to do so. DRINK will recruit 50 participants who will randomly (much like tossing a coin) be allocated to either the high water intake group (HW) or the ad libitum water intake group (AW). The HW group will be given a personalised daily water prescription (usually between 2-4 litres), to produce dilute enough urine to stop vasopressin being made by the body. Those allocated to the AW group will continue to drink as they normally would. As part of the trial participants will have clinic visits, blood tests, urine tests and questionnaires to fill out. If successful, we will use the information from DRINK to plan a large trial to work out whether high water intake can slow cyst growth and kidney damage in ADPKD in the long term. We will be advertising nationally for participants, please see our contact details if you would like more information about the trial or participation.